Alone Together Then and Now

Alone Together Then and Now

1708 Emerging Infectious Diseases • www.cdc.gov/eid • Vol. 15, No. 10, October 2009 “Sickly, neurotic, and so myopic that he is afraid of losing his sight; but for this very reason an eminently receptive creature and sensitive to the character of things,” wrote French writer and art critic Edmond de Goncourt about Edgar Degas. The artist knew his own difficult nature. “[I have] one terrible, ir...

Schizophrenia: Then and Now

EPS—Then and Now

"Slime" played a brief and spectacular role in the 19th century founded by the theory of primordial slime by Ernst Haeckel. However, that substance was never found and eventually abandoned. Further scientific attention slowly began in the 1930s referring to slime as a microbial product and then was inspired by "How bacteria stick" by Costerton et al. in 1978, and the matrix material was conside...

Then and Now

Fluoroquinolones: then and now.

Fluoroquinolones were discovered in the 1960s as a derivative of the antimalarial drug chloroquine. Over the past 40 years, many fluoroquinolones have been developed for use in human and veterinary medicine. As with all classes of antibiotics, resistance to fluoroquinolones is a serious concern, and multiple avenues for resistance are being investigated. Resistance-associated point mutations in...